SLE is an autoimmune disease, not cancer. The peak incidence of the disease 15-45 years of age, more common in women, male to female ratio is 1:9, the ratio of men and women of childbearing age
1:30. Pathogenesis of SLE and genetic, estrogen levels, ultraviolet radiation, certain foods and infection and other factors. Which genetic factors in the pathogenesis of SLE has an important role.