Drug NameCommon name: gastrodin capsule
English name: Gastrodin Capsules
Hanyu Pinyin: Tianmasu Jiaonang
This product is the main component: gastrodin.
Chemical name: 4 - hydroxyphenyl-β-D glucopyranoside.
Molecular formula: C13H18O7
Molecular weight: 295.38
CharactersThis product capsules, built of white granules or powder. the
toxicologicalPharmacology: Pharmacological experiments show that excitation and inhibition gastrodin recoverable cerebral cortex imbalance between the process, with sedative, hypnotic and analgesic central inhibition. Toxicology: Acute toxicity test: mice by oral or intravenous injection of gastrodin dose used 5000mg/kg, observe the three days, no poisoning and death. Subacute toxicity test: 4 to 6 days in dogs and mice administered, blood tests, red blood cells, white blood cell and platelet counts had no effect. Determination of blood tests had no effect on alanine aminotransferase, protein and cholesterol. The animal's heart, lungs, spleen, liver, kidney, stomach and intestinal tissue section examination, no cell degeneration. These results suggest that gastrodin the hematopoietic system, liver, renal function and blood lipids had no effect.
pharmacokineticsMice fed after gastrodin, disappeared from the gastrointestinal tract quickly, the only 5.2% of the dose after two hours, the blood rising rapidly, t1/2α is only six minutes to maintain a high level before and after one hour, and the time of the sedative effect in mice, elimination half-life of intravenous 4.44 hours, oral for 7.47 hours. In vivo distribution in kidney, followed by liver, lung, heart, spleen and brain. From the urine 24 hours after the administration from the discharge of urine, feces and bile 76.8% of the total administered dose, in which the urine of 97%, mainly the first two hours, very little bile and feces.
indications for neurasthenia, neurasthenic syndrome and angioneurotic headache embolism (such as migraine, trigeminal neuralgia, occipital neuralgia, etc.).
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