Desensitization therapy, also known as desensitization or specific immune treatment is unavoidable and skin test or other means confirmed or suspected major antigenic substance, made of a certain concentration of the leaching solution to gradually increasing doses and the concentration method of injection, repeated to the patient is injected with specific antigen, prompting the body to produce antibodies.
Introductionthese antibodies are IgG type, these specific antibodies increased in body fluids, such as re-accept the alien-specific allergen, these antibodies first bind to the IgE antibody competition with the body of the original, resulting in the immune response rather than an allergic reaction. Gradually decreased after continuous desensitization therapy, the serum IgE and allergic reactions below the threshold, which can prevent allergic reactions occur, and thus to achieve desensitization purpose.
applicable indesensitization therapy is best for the inhalation of allergen-induced allergic rhinitis or allergic asthma, inhalant allergens released into the atmosphere everywhere, difficult to avoid, so the use of desensitization therapy is a preventive asthma relapse important measures. The how
1, to identify allergensfirst to identify the allergen, the current method of looking for allergens are mainly the following four:
1. intradermal method
2. intradermal threshold method
3. caught needling
4. a variety of allergy tests at the same time-specific antibodies
5 skin points thorn experiment, the Act more commonly used in clinical
currently the most used a variety of specific antibodies in allergy testing and skin point barbed experiment. The former is safe and convenient, high specificity, the needs of the patients about 6c.c. blood samples can detect 20 to 35 different allergens reaction; latter intuitive response to the body's allergies, test results 15 minutes out.
treatmentIn determining what kinds of allergens, you can select the appropriate allergen desensitization therapy.
sublingual sublingual desensitization therapy
2001, WHO published the white paper says that sublingual desensitization completely replace the traditional subcutaneous therapy. Sublingual desensitization therapy is currently only for dust mites and house dust mite allergic patients. The Act is safer to use, the patient compliance. Use as follows: according to different ages use different maintenance dose. Relatively fixed time each day drops under the tongue sublingual 1-3 minutes, easy to use. Incremental phase of the dose is divided into 1, 2 and 3. The maintenance dose is divided into 4 and 5. Generally maintain the age of 14 on the 4th, to maintain over the age of 14 on the 5th.
dust mites cause allergic rhinitis, allergic asthma, allergic conjunctivitis, allergic rash, allergic urticaria, allergic conjunctivitis. Change patients after in vivo immunological parameters before and after sublingual dust mite immunotherapy sublingual mucosal tissue and thinner in the mucosal surface of Langerhans cells in contact with the antigen capture enough to allergens signal allergen vaccine can rapidly absorb, in order to start the desensitization response. Including serum IgG4 levels rise, the Th2/Th1 cell ratio improvement. By sublingual administration, usually do not produce anaphylactic shock and other serious adverse reactions, a very small number of patients with occasional mild rash or mild diarrhea, stop the treatment or reduction can be restored. The mechanisms of sublingual desensitization therapy is because the sublingual mucosa the number of Langerhans cells, by absorption of micro-dust mite allergen original after its processing into mites peptide information presented to the Th0 cells, so that Th0 cells to Th1 cells into to prevent the occurrence of allergy.
sublingual desensitization and sublingual desensitization therapy is the purpose of instillation of allergen extract sublingual tolerance to the respiratory mucosa, so as to reduce or control allergy symptoms, desensitization therapy is reached . Its clinical features are:
the fastest growing desensitization therapy (ie, specific immunotherapy or immunosuppressive therapy), in line with World Health Organization recommended symptomatic + due to the rational treatment plan.
tackling the problem: a fundamental treatment of allergic disease, the onset of significant, the desensitization thorough; to overcome the traditional hormonal chemicals in disease onset, only symptomatic treatment, palliatives limitations, and with the take time, with varying degrees of adverse reactions may have some resistance.
security: a global scale, used for 30 years is not serious side effects, the maximum degree of protection desensitization treatment of long-term drug safety; avoid injectable desensitization therapy may cause serious adverse systemic reactions (including anaphylactic shock and even death), so as to reduce the psychological burden of health care workers and patients.
the course of development of the
desensitization therapy 1909, Noon to use the auto-immune treatment of pollen rhinitis to be successful, creating a new era of immunotherapy. After half a century of practice, immunotherapy shows some of the clinical effect, but since the 1980s, the United Kingdom the number of cases of deaths due to injection immunotherapy agents, leading to relevant government agencies ordered a total ban on immunotherapy .
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