Overview: generalized eruptive histiocytosis (General Eruptive Histiocytosis, GEH) as a papular, non-lipid nature, self-healing histiocytosis, occurs mainly in adults. 1963 by Winkelmann and Muller first reported a case of adults; 1987 Paputo other previously reported series of children's cases. The disease is extremely rare, reported in the literature about 30 cases, of which 7 were children.
can occur at any age, asymptomatic lesions of the round or oval papules or nodules form, yellow or dark blue, solid nature, size 3 ~ 10mm . Successive groups of lesions, the number can be up to several hundred. Adult lesions, symmetrically distributed on the trunk and limbs, even to violate mucosa. Children's skinlesions irregularly distributed in the body, mucous membranes are not violated. Not involving the internal organs of adults and children. skinlesions for several years, may gradually subside.
Histopathology: dermal papilla and dermal layer of the middle shows monomorphic cells and few lymphocytes. No multinucleated giant cells. Sparse nuclear chromatin organization, abundant cytoplasm, lightly stained, ill-defined cytoplasm. These cells often arranged in nests around the blood vessels. immunohistochemical examination of infiltrating cells in S-100 protein and CD1a (OKT-6) negative, CD-11b and CD-4 positive. AMD examination showed clusters of tumor cells containing large amounts of dense lamellar body rules, even visible insect-like body, no Birbeck granules. tissuelipidstain was negative.