medical adhesive Overview1.1 medical glue the definition of the international contact with the medical supplies used to make the human physiological environment (human tissue and blood) are collectively referred to as biomedical engineering materials in China management as a class III medical devices.
1.2 medical adhesive classification and standardsaccording to the 2005 Chinese medical device regulations and supervision guidelines, medical plastic in medical devices classified as Class III in 6865-3, including Medical α-cyanoacrylate, and the blessing Philharmonic medical adhesive standards YZB/country 0941-2003 as a state only recognized medical adhesive testing standards.
1.3 medical adhesive development history and status quoIn the surgery, antimicrobial, hemostatic is the basis of biological tissue repair, sewing, tie two basic operation of this method is not only cumbersome and laborious, and could easily lead to bleeding and damage to bring more pain to the patient; for those who can not find the bleeding point The area of bleeding, the doctors could do nothing. Use adhesive to replace or partially replace the suture can be stopped using the spray adhesive oozing or closed cancer serosa of the small blood vessels, will be a revolution in surgery, the last century, in order to find an ideal medical adhesive made unremitting efforts.
today, people have developed thousands of adhesives, but can be suitable for medical indeed few are strict medical index card out.
Eastman910 produced by the Eastman Kodak Company, USA in 1959 (of α-cyano-methacrylate) instant adhesion to attract the medical profession.
1960, Nathan et al first used for arterial anastomosis , approved by the FDA in 1972 (α-cyanoacrylate, isobutyl) medical and then Ding only , until johnson & johnson in 2003 to our country to apply for FDA approval epidermal adhesive (2-OCA) (α-cyanoacrylate Chung-ethylhexyl) (2-Octyl Cyanoacrylate) to enter the beijing Union Medical College Hospital, but the price high and is limited to epidermal application has been neglected 
1963 the japanese Ministry of Health approved Hikaru フ of the ァ ロ nn ァ ァ A "Sankyo" (α-cyanoacrylate B/n-butyl) as a dental adhesive and surgical glue. Successively produced by Germany B.Braun blue plastic Histoacry the Blau (α-butyl cyanoacrylate), 1994 is priced at 375 yuan/0.5ml., 2000 in Germany ä Meyer-H & auml; k Ë company imports to China EPIGLU
1966 China's Liaoning Province Gaixian <661> (α-cyanoacrylate, isobutyl) (IBCA), 1994 wing city of Henan Province science and Technology experiment Factory/Beijing blink Sport Technology Development Co., Ltd., chairman of Mr. Chen Tiyi invented the medical adhesive of the country and the world recognized instantaneous Kang, 1999 and later appeared in succession (Kang Pat) (Branch) - Yichang Sheng Kang, medical adhesive products, the main rubber are (IBCA).
Shaanxi Province in 1971, the first produced by shanghai xinyi Pharmaceutical <504> (N-BCA) (α-cyano-n-butyl acrylate) is used for tubal sticky blocking sterilization, clinically proven < ; 504> polymerization is too fast a doctor too late to operate, hard and brittle, of the polymer monomer viscosity easy flowing, non-imaging insufficient in the 1974 national family planning work conference, lin jia mei and lin Qiaozhi proposed to be <504> modified before re-entering the human body. January 1978 at the Xi'an Institute of chemical engineering honor to preside over female sterilization sticky blocking agents and the men and women after sterilization stick blocking agent sixty-five technology research projects, access a large number of British, Japanese, russian German data, inspired by the Soviet Union a paper: high-carbon ester (506) can change the performance of low-carbon ester (501). can use α-cyanoacrylate octyl <508> (N -OCA) (N-octyl-α-Cyanoacrylate) change (504) the performance of the 200 synthetic test, we developed a purity of only 92% of the <508> monomer (by IR, NMR, elemental analysis), but also 84 formulation screening, developed in 1978 out of tubal sterilization stick blocking agent, referred to as the J-2 glue [4.5]. into the clinic on the basis of animal tests are successful then the development of successful men, J-3 glue [6.7] .. 1980 - 1983 by the Fourth military medical University, wuhan Tongji Medical College, Tianjin labor Health Institute, in the absence of any modern toxicology test reference case, the acute toxicity, sub-acute toxicity, chromosomal aberrations, and promote cancer, caused by (mutagenic, teratogenic, carcinogenic), reproduction and other test results were negative. completed by the Second Affiliated Hospital of Xi'an Medical antibacterial test (Staphylococcus aureus, white aureus Courtyard associated coccus, hemolytic streptococcus, A streptococcus, Streptococcus pneumoniae, Escherichia coli, proteus mirabilis, bacillus subtilis, pseudomonas aeruginosa, yeast, etc.) 11 kinds of bacteria in the formation of inhibition zone, Xi'an Medical freshman on the basis of the above biological tests , Second Affiliated Hospital, Xi'an, II, IV, Central Hospital, four medical Xijing Hospital, Tang du Hospital, Tongji Medical College, the First Hospital of Suzhou University, Shenyang, China Medical freshman Hospital, Fujian Nanping City Hospital shanghai Ruijin Hospital, Institute of dense anorectal hospitals hundreds of doctors, led by the famous organ transplant scientist Professor xia Suisheng the full assistance of 10 years (1978-1988), we developed: the J-2 plastic J-3 glue, developing CD plastic, ZT glue, plastic V-1, V-2 glue, TH plastic eye with plastic, OB glue, BC glue, Spray PW glue, ec glue, the F-TH glue, D -TH glue, ZM glue, hernia glue, such as <508> series of medical glue into the clinic 20 sections of approximately 1 million cases, only the J-3 glue in 13 cities and counties in Shaanxi Province reached 100,000 cases. [8.9] 1988-1989 in Xi'an, we held a seminar of the two medical adhesive, medical adhesive applied research a new milestone; has clinical full penetration of the 1991 medical adhesive Research Center south to Shenzhen and Guangzhou (1993) to achieve the transformation of the scientific research enterprise. (1993-1996), 3-4 seminar .5 seminar held in Guangzhou received a total of 625 hospital departments have doctors with plastic surgery routine with plastic  In 1994 a series of medical adhesive through national production appraisal, medical α-cyano-acrylate is included in the 1997 version of the national medical device Categories III class 6865-3. If 504 monomer as the first generation of medical adhesive 508 is the main glue a series of plastic as the second generation of medical adhesive, 2002 in beijing Zhongguancun high-tech Park, we have developed the spray-type fu Philharmonic medical adhesive could name the third generation of medical adhesive ─ blessing Philharmonic medical adhesive standards YZB/country 0941-2003 is listed as a country only recognized medical adhesive testing standards  clinical needs and doctors creative, medical adhesive Therapy 
2 blessing Philharmonic medical adhesive (FAL)
2.1 compositionthe FAL optimized composition (: development of purity> 99% monomer), rubber performance [33-37]
the FAL by the high-purity α-cyanoacrylate, octyl (N-OCA) and α-cyanoacrylate n-butyl (of N-BCA). get rid of the second generation of medical glue 502, DTDP, plexiglass, freon and other various additives in the formula. The FAL curing time for the 2-6S (time to operation), the proliferation of performance closed the toughness of the polymer film bending 180 degrees of fracture, low polymerization heat, the adhesive strength to meet the clinical requirements.
2.2 FAL perfect sterile supporting Tools and Specificationsdeveloped with plastic tools handy (were patent) [33-37], spray freely, As noted in the different clinical requirements, the doctor can choose the appropriate specifications.
the FAL specifications
smear type 0.5ml/sets
spray type 1.0ml/setsendoscopic type 1.5ml/
FAL clinical application FAL improved monomer purity, optimizing the overall performance of medical adhesive, equipped with a variety of applicable tools, medical adhesive as will supplies in many departments, has developed into a school for the treatment of medical adhesive is widely used in general surgery, laparoscopy, neurosurgery, cardiothoracic, maternity, urology, orthopedics, mouth, nose, throat, burns plastic 20 sections surgery with hemostasis, closed bonding, the role of plugging, thrombosis, anti-adhesion, fixed comminuted etc. (limited space for another introduction.)
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