Overview: livedo reticularis (livedo reticularis) is a local because the skin vasomotor dysfunction, resulting in a small artery spasm and small vein dilation, blood stasis and the limitations of the skin appear blue, purple livedo reticularis. according to their clinical characteristics, divided into primary and secondary, the former as a physiological phenomenon, common in normal children and adult women; the latter for a number of diseases of the skin manifestations.[Cause]
livedo reticularis is what causes it?
2. livedo reticularis secondary disease may be secondary to many diseases, its pathogenesis is unclear. The most common autoimmune rheumatic disease (nodular periarteritis, rheumatoid arthritis, systemic lupus erythematosus, temporal arteritis), atherosclerosis, increased blood viscosity disease (polycythemia vera, thrombocythemia, cold agglutinin anemia, cryoglobulinemia, macroglobulinemia, etc.), venous disorders (superficial phlebitis, skin vasculitis), as well as burns, radiation, heat injury, congenital capillary expansion of the psychosis.
(B) the pathogenesis
(1) or antiphospholipid antibody syndrome within the Division of Registration (Sneddon) syndrome, due to skin small artery endothelial proliferation leading to luminal stenosis, there livedo reticularis.
(4) by the streptococcus, tuberculosis, hepatitis virus-induced allergic changes in small blood vessels, or by the tiny virus (parvovirus B19) directly caused by small changes in vessel wall have been reported.
(1) small vessel thrombosis is most common in connective tissue disease or abnormal immunoglobulin antibody-positive patients, antiphospholipid antibody syndrome were more common, including myocardial phospholipid antibodies, lupus anti-antibody and anti-β2-glycoprotein 1 antibodies, antibody-positive in more than a few more than half of the skin livedo reticularis performance.
(2) multiple small blood vessels through the femoral artery embolization and more as a variety of catheter angiography or interventional procedures, leading to the aorta, subclavian artery and other atherosclerotic plaque rupture caused by shedding of cholesterol crystals, followed by a number of primary renal failure patients prone to nocturnal high oxalic acid, oxalic acid crystals can lead to microvascular plugging bolt livedo reticularis.
(3) of the skin due to drug allergy cause livedo reticularis, skin biopsy has been confirmed by thrombosis, a known drug for acne minocycline (minocycline ), ergotamine treatment of migraine, a variety of β-blockers and some anti-tumor chemotherapy drugs, etc., there are other individual reported combined diethyl pyridine-dione diphenhydramine, amantadine and some hypnotics and so on.
(2) blood protein C deficiency, complement 1 inhibitor deficiency leads to vice hypoproteinemia, macroglobulinemia, cryoglobulinemia, anti-familial thromboxane Ⅲ deficiency, idiopathic thrombocythemia and diabetes, also can occur.
4. after birth the skin that may have livedo reticularis, congenital livedo reticularis as by long-term (8 to 21 years) observation can be found in other systems diseases such as cerebral infarction, hypertension, glaucoma, kidney damage, but the reason is unknown.
livedo reticularis early symptoms?
2. primary livedo reticularis, the patient showed gradual emergence of flaky skin, striped mesh or patchy stripes, veins clear, and some slightly higher than the leather, can occur in any part of the trunk and limbs, but the most common lower extremity. Local skin bruising, may have cold or numbness, paresthesia, but the extent is not heavy, usually no pain, and sometimes increased sweating. In a cold environment, when standing or drooping skin bruising physical network spot obvious, warm environment or Taigaohuanzhi is slightly better, but not completely disappeared, and the corresponding parts of the main arteries, such as the upper brachial artery, radial artery, lower extremity femoral artery,[Aftertreat]
livedo reticularis ate?[Prevent]
livedo reticularis should be how to prevent?
2. should be the local thermal protection against cold.
livedo reticularis precautions before treatment?
1. primary livedo reticularis in patients given only symptomatic treatment, such as general Note the skin warm and avoid exposure to cold environment will cut out, cut out to prevent the formation of skin ulcers. Can be applied to vasodilator drugs, such as anisodamine, niacin (tobacco acid), niacin inositol (niacin inositol lipid), dextran 40 (dextran) and Mailuoning, also can be applied to Chinese herbs, such as blood circulation Salvia, safflower, chuanxiong and so on.
2. secondary to various systemic diseases, systemic or secondary livedo reticularis patients, the cause of drug allergy should be given according to specific treatment, while to give the drug to improve skin microcirculation, and local warmth and so on.
(b) the prognosis
primary livedo reticularis of the natural prognosis of patients, duration of general last for months or years and relieve itself. secondary to systemic disease or livedo reticularis systemic prognosis of patients with primary disease are closely related.
livedo reticularis should do what check?
1. based on the possible cause, select the relevant blood, urine and biochemical tests, the diagnosis of the cause is often important.
2. cerebrospinal fluid routine examination than non-specific.
3. immunizations check auxiliary and differential diagnosis.
livedo reticularis and the diseases easily confused?
2. raynaud's disease disease is more common in women. Many originating in the hand, originating in the foot are rare. Onset of cold hands and feet, with pale skin, bruising and flushing phase changes, often accompanied by numbness, pins and needles. Onset of the gap period (toe) may have pain and tingling burning sensation. As the long-term repeated attacks, nutritional disorders, (toe) side appeared superficial necrosis or ulceration, pain more intense. In particular, changes in skin color and different with livedo reticularis.
3. hand, foot and hand, foot and skin cyanosis cyanosis continuous symmetric color, touch the wet, winter increase, occurred in young women, the normal limb pulse characteristics such as disease-oriented.[Disease]
livedo reticularis may be taken up by diseases?
livedo reticularis related diseases
more skin symptoms
depression depressed scars scar scar damage after itching scar contraction depressed scars scars old age acne scarring rash maculopapular rash of the skin lesions after exposure back zhangdou nasolabial red chapped skin lichen planus calcification of epidermal keratinocytes full thickness skin necrosis and exfoliation of the table dermatitis, pellagra-like rash
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